Obesity is associated with higher extracellular fluid (ECF) compared to intracellular fluid (ICF) volume and this dysregulation is associated with hypertension and abdominal obesity, associated with metabolic syndrome. As sodium is predominantly an extracellular cation, a higher ECF/ICF ratio will lower serum sodium concentration. The aim of the study was to see whether weight loss, due to dieting and bariatric surgery, had any impact on serum sodium concentrations in patients with severe obesity.
Patients with a BMI ?35kg/madmitted for bariatric surgery at Innlandet Hospital Trust, Norway during 2012-14 were included in the study (n=119). Clinical data and blood samples were recorded at inclusion, after mean six months of dieting, as well as six and 12 months after bariatric surgery.
At inclusion, mean serum sodium was in the lower normal range, 138.3 (SD 2.4) mmol/L, but increased to 141.8 (SD 1.9) mmol/L after weight loss. The increase was significantly correlated to total weight loss (rho 0.29, p=0.007). Twelve months after surgery, serum sodium was significantly higher in patients with a normal BMI (&lt;25kg/m) compared to patients with overweight.
Obesity and hypertension are associated with body fluid dysregulation affecting serum sodium concentrations. As mild hyponatremia, even within the normal sodium range, is associated with increased total mortality and major cardiovascular disease events, serum sodium might be a potential risk marker in patients with obesity.
Obesity and hypertension are associated with body fluid dysregulation affecting serum sodium concentrations. As mild hyponatremia, even within the normal sodium range, is associated with increased total mortality and major cardiovascular disease events, serum sodium might be a potential risk marker in patients with obesity.Studies have been conducted with the purpose of elucidating thyroid gland dysfunction in obesity, however the contributing factors for such dysfunction are not yet fully understood. Selenium is notable for its role in thyrocyte protection against oxidative damage and control of thyroid hormone synthesis. In addition, subjects with obesity may exhibit alterations in the selenium homeostasis. Therefore, the present study aimed to examine the selenium status and its relationship with serum thyroid hormone levels in obese women.
This cross-sectional study included 69 euthyroid women, aged between 18 and 50 years, who were divided in two groups an obese group (n=35) and a control group with women of normal weight (n=34). Selenium intake was assessed by three-day diet records and analyzed using NutWin software version 1.5. Plasma, erythrocyte, and urinary selenium levels were determined using inductively coupled plasma optical emission spectrometry. Testing for thyroid hormones and thyroid autoantibodies was performed based on chemiluminescence.
The median dietary selenium content was adequate according to the recommendations, with no statistical difference between groups. Obese women had reduced plasma and erythrocyte selenium levels compared to the control group, although selenium concentration in erythrocytes was adequate within the normal range for both groups. There was no significant difference between the urinary selenium concentrations in the subjects; however, the mineral clearance was higher in the obese group. Free triiodothyronine (fT3) and free thyroxine (fT4) levels were higher in obese women with class II obesity when compared to the control group. There was a negative correlation between plasma selenium and serum fT4 levels.
Obese women showed impairment in selenium homeostasis, however, this fact did not seem to adversely affect thyroid metabolism.
Obese women showed impairment in selenium homeostasis, however, this fact did not seem to adversely affect thyroid metabolism.Improving sleep quality is important for an aging society. However, no study has been conducted on the association between dietary variety and sleep efficiency among older Japanese adults using longitudinal data. The current study is a longitudinal study that aimed to elucidate the association between dietary variety and sleep efficiency in older Japanese adults.
This study was conducted among older adults (?70 years old in 2016) in the metropolitan area of Tokyo, Japan, between 2016 and 2018. Dietary variety score (DVS) and sleep efficiency were determined for all participants and were used to assess dietary habits and sleep quality, respectively. A cross-lagged panel analysis was used to consider the prospective associations between DVS and sleep efficiency, and this analysis was performed before and after adjusting for possible covariates in the 2016 data.
After adjusting for age, sex, body mass index, current drinking status, current smoking status, exercise habits, living (alone or with others) style, the Japanese version of the Geriatric Depression Scale (Short Form), sleep duration and retiring time the DVS in 2016 predicted the sleep efficiency in 2018 (β=0.130, p&lt;0.05).
The possibility that DVS can predict sleep efficiency 2 years later was demonstrated.
The possibility that DVS can predict sleep efficiency 2 years later was demonstrated.Metabolic syndrome (MetS) is a clinical disorder with widespread prevalence. In the current study, we aimed to investigate the association between serum soluble P-selectin, procalcitonin, transforming growth factor (TGF)-β and apo-proteins with the components of metabolic syndrome in obese individuals.
Sixty two obese patients with MetS and sixty five obese apparently healthy controls were participated in the current case-control study. The participants' anthropometric assessments and systolic and diastolic blood pressure (SBP and DBP) were measured. Serum lipids and the concentrations of ox-LDL, P-selectin, procalcitonin, TGF-β and apo-proteins were measured with commercial ELIZA kits.
Serum TG and TC were significantly higher in obese subjects with MetS; while TGF-β, procalcitonin, apoprotein B and insulin concentrations were higher in obese non- MetS group. In obese subjects with MetS, procalcitonin was in positive association with ox-LDL and apoprotein-B was in positive association with HDL. https://www.selleckchem.com/products/chir-99021-ct99021-hcl.html In obese subjects without MetS, apoprotein -B was in positive association with WC and HDL and WC.